Age-related macular degeneration (AMD), which results in irreversible central vision loss, can impact many day-to-day activities like face recognition, reading, driving, etc.1 Patients with AMD may have to use a non-foveal eccentric location, the preferred retinal locus for fixation and other visual tasks. Fixational eye movements in people with central vision loss is primarily affected in that the amplitude of these tiny involuntary eye movements is larger than that in people with normal vision3. Because fixation stability (FS) has become an outcome measure in rehabilitation and intervention for patients with AMD, it is important to ensure that the quantification of FS is accurate. Several factors such as recording duration4,5, recording instrument and its characteristics (e.g.: sampling rate) can hamper proper recording and interpretation of FS.
In this study, we will utilize several commercially available instruments, OPKOS OCT/SLO6 and eye trackers (EyeLink II and 1000+7) to study the FS in both typically sighted and visually impaired subjects. Specifically, we propose to determine the influence of duration and sampling rate on the FS. Such understanding of the FS may help us better interpret and compare the measurements.